研究業績

  • Yoshioka, T., Igarashi, Y., Namba, T., Ueda, S., Pait, I. G. U., Nihira, T., and Kitani, S. (2021) Lavencidin, a polyene macrolide antibiotic from Streptomyces lavendulae FRI-5. J Antibiot (Tokyo) 74, 359-362
  • Machihara, K., and Namba, T*. (2020) Kuanoniamine C stimulates bortezomib-induced cell death via suppression of glucose-regulated protein 78 in osteosarcoma. Biochem Biophys Res Commun 527, 289-296
  • Ueda, S., Ikeda, H., Namba, T., Ikejiri, Y., Nishimoto, Y., Arai, M., Nihira, T., and Kitani, S. (2019) Identification of biosynthetic genes for the beta-carboline alkaloid kitasetaline and production of the fluorinated derivatives by heterologous expression. J Ind Microbiol Biotechnol 46, 739-750
  • Namba, T*. (2019) BAP31 regulates mitochondrial function via interaction with Tom40 within ER-mitochondria contact sites. Science Advances 5, eaaw1386
  • Machihara, K., and Namba, T*. (2019) BAP31 Inhibits Cell Adaptation to ER Stress Conditions, Negatively Regulating Autophagy Induction by Interaction with STX17. Cells 8
  • Ueda, S., Kitani, S., Namba, T., Arai, M., Ikeda, H., and Nihira, T. (2018) Engineered production of kitasetalic acid, a new tetrahydro-beta-carboline with the ability to suppress glucose-regulated protein synthesis. J Antibiot (Tokyo) 71, 854-861
  • Namba, T*., Kodama, R., Moritomo, S., Hoshino, T., and Mizushima, T. (2015) Zidovudine, an anti-viral drug, resensitizes gemcitabine-resistant pancreatic cancer cells to gemcitabine by inhibition of the Akt-GSK3beta-Snail pathway. Cell Death Dis 6, e1795
  • Namba, T*., and Kodama, R. (2015) Avarol induces apoptosis in pancreatic ductal adenocarcinoma cells by activating PERK-eIF2alpha-CHOP signaling. Mar Drugs 13, 2376-2389
  • Namba, T*., Chu, K., Kodama, R., Byun, S., Yoon, K. W., Hiraki, M., Mandinova, A., and Lee, S. W. (2015) Loss of p53 enhances the function of the endoplasmic reticulum through activation of the IRE1alpha/XBP1 pathway. Oncotarget 6, 19990-20001
  • Namba, T. (2015) Regulation of endoplasmic reticulum functions. Aging (Albany NY) 7, 901-902
  • Kakigano, A., Tomimatsu, T., Mimura, K., Kanayama, T., Fujita, S., Minato, K., Kumasawa, K., Taniguchi, Y., Kanagawa, T., Endo, M., Ishihara, T., Namba, T., Mizushima, T., and Kimura, T. (2015) Drug Repositioning for Preeclampsia Therapeutics by In Vitro Screening: Phosphodiesterase-5 Inhibitor Vardenafil Restores Endothelial Dysfunction via Induction of Placental Growth Factor. Reprod Sci 22, 1272-1280
  • Hiraki, M., Hwang, S. Y., Cao, S., Ramadhar, T. R., Byun, S., Yoon, K. W., Lee, J. H., Chu, K., Gurkar, A. U., Kolev, V., Zhang, J., Namba, T., Murphy, M. E., Newman, D. J., Mandinova, A., Clardy, J., and Lee, S. W. (2015) Small-Molecule Reactivation of Mutant p53 to Wild-Type-like p53 through the p53-Hsp40 Regulatory Axis. Chem Biol 22, 1206-1216
  • Byun, S., Namba, T., and Lee, S. W. (2015) Losing p53 loosens up ER-stress. Aging (Albany NY) 7, 895-896
  • Namba, T., Tian, F., Chu, K., Hwang, S. Y., Yoon, K. W., Byun, S., Hiraki, M., Mandinova, A., and Lee, S. W. (2013) CDIP1-BAP31 complex transduces apoptotic signals from endoplasmic reticulum to mitochondria under endoplasmic reticulum stress. Cell Rep 5, 331-339
  • Brown-Endres, L., Schoenfeld, D., Tian, F., Kim, H. G., Namba, T., Munoz-Fontela, C., Mandinova, A., Aaronson, S. A., and Lee, S. W. (2012) Expression of the p53 target CDIP correlates with sensitivity to TNFalpha-induced apoptosis in cancer cells. Cancer Res 72, 2373-2382
  • Tanaka, K., Tanaka, Y., Miyazaki, Y., Namba, T., Sato, K., Aoshiba, K., Azuma, A., and Mizushima, T. (2011) Therapeutic effect of lecithinized superoxide dismutase on pulmonary emphysema. J Pharmacol Exp Ther 338, 810-818
  • Takehara, M., Hoshino, T., Namba, T., Yamakawa, N., and Mizushima, T. (2011) Acetaminophen-induced differentiation of human breast cancer stem cells and inhibition of tumor xenograft growth in mice. Biochem Pharmacol 81, 1124-1135
  • Namba, T., Tanaka, K., Hoshino, T., Azuma, A., and Mizushima, T. (2011) Suppression of expression of heat shock protein 70 by gefitinib and its contribution to pulmonary fibrosis. PLoS One 6, e27296
  • Hoshino, T., Murao, N., Namba, T., Takehara, M., Adachi, H., Katsuno, M., Sobue, G., Matsushima, T., Suzuki, T., and Mizushima, T. (2011) Suppression of Alzheimer's disease-related phenotypes by expression of heat shock protein 70 in mice. J Neurosci 31, 5225-5234
  • Tanaka, K., Tanaka, Y., Namba, T., Azuma, A., and Mizushima, T. (2010) Heat shock protein 70 protects against bleomycin-induced pulmonary fibrosis in mice. Biochem Pharmacol 80, 920-931
  • Tanaka, K., Ishihara, T., Azuma, A., Kudoh, S., Ebina, M., Nukiwa, T., Sugiyama, Y., Tasaka, Y., Namba, T., Ishihara, T., Sato, K., Mizushima, Y., and Mizushima, T. (2010) Therapeutic effect of lecithinized superoxide dismutase on bleomycin-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 298, L348-360
  • Namba, T., Tanaka, K. I., Ito, Y., Hoshino, T., Matoyama, M., Yamakawa, N., Isohama, Y., Azuma, A., and Mizushima, T. (2010) Induction of EMT-like phenotypes by an active metabolite of leflunomide and its contribution to pulmonary fibrosis. Cell Death Differ 17, 1882-1895
  • Namba, T., Hoshino, T., Suemasu, S., Takarada-Iemata, M., Hori, O., Nakagata, N., Yanaka, A., and Mizushima, T. (2010) Suppression of expression of endoplasmic reticulum chaperones by Helicobacter pylori and its role in exacerbation of non-steroidal anti-inflammatory drug-induced gastric lesions. J Biol Chem 285, 37302-37313
  • Suemasu, S., Tanaka, K., Namba, T., Ishihara, T., Katsu, T., Fujimoto, M., Adachi, H., Sobue, G., Takeuchi, K., Nakai, A., and Mizushima, T. (2009) A role for HSP70 in protecting against indomethacin-induced gastric lesions. J Biol Chem 284, 19705-19715
  • Namba, T., Tanaka, K., Ito, Y., Ishihara, T., Hoshino, T., Gotoh, T., Endo, M., Sato, K., and Mizushima, T. (2009) Positive role of CCAAT/enhancer-binding protein homologous protein, a transcription factor involved in the endoplasmic reticulum stress response in the development of colitis. Am J Pathol 174, 1786-1798
  • Namba, T., Homan, T., Nishimura, T., Mima, S., Hoshino, T., and Mizushima, T. (2009) Up-regulation of S100P expression by non-steroidal anti-inflammatory drugs and its role in anti-tumorigenic effects. J Biol Chem 284, 4158-4167
  • Ishihara, T., Tanaka, K., Tasaka, Y., Namba, T., Suzuki, J., Ishihara, T., Okamoto, S., Hibi, T., Takenaga, M., Igarashi, R., Sato, K., Mizushima, Y., and Mizushima, T. (2009) Therapeutic effect of lecithinized superoxide dismutase against colitis. J Pharmacol Exp Ther 328, 152-164
  • Hoshino, T., Namba, T., Takehara, M., Nakaya, T., Sugimoto, Y., Araki, W., Narumiya, S., Suzuki, T., and Mizushima, T. (2009) Prostaglandin E2 stimulates the production of amyloid-beta peptides through internalization of the EP4 receptor. J Biol Chem 284, 18493-18502
  • Ushijima, H., Hiasa, M., Namba, T., Hwang, H. J., Hoshino, T., Mima, S., Tsuchiya, T., Moriyama, Y., and Mizushima, T. (2008) Expression and function of TETRAN, a new type of membrane transporter. Biochem Biophys Res Commun 374, 325-330
  • Tanaka, K., Namba, T., Arai, Y., Fujimoto, M., Adachi, H., Sobue, G., Takeuchi, K., Nakai, A., and Mizushima, T. (2007) Genetic evidence for a protective role for heat shock factor 1 and heat shock protein 70 against colitis. J Biol Chem 282, 23240-23252
  • Namba, T., Ishihara, T., Tanaka, K., Hoshino, T., and Mizushima, T. (2007) Transcriptional activation of ATF6 by endoplasmic reticulum stressors. Biochem Biophys Res Commun 355, 543-548
  • Namba, T., Hoshino, T., Tanaka, K., Tsutsumi, S., Ishihara, T., Mima, S., Suzuki, K., Ogawa, S., and Mizushima, T. (2007) Up-regulation of 150-kDa oxygen-regulated protein by celecoxib in human gastric carcinoma cells. Mol Pharmacol 71, 860-870
  • Ishihara, T., Hoshino, T., Namba, T., Tanaka, K., and Mizushima, T. (2007) Involvement of up-regulation of PUMA in non-steroidal anti-inflammatory drug-induced apoptosis. Biochem Biophys Res Commun 356, 711-717
  • Tsutsumi, S., Namba, T., Tanaka, K. I., Arai, Y., Ishihara, T., Aburaya, M., Mima, S., Hoshino, T., and Mizushima, T. (2006) Celecoxib upregulates endoplasmic reticulum chaperones that inhibit celecoxib-induced apoptosis in human gastric cells. Oncogene 25, 1018-1029
  • Tanaka, K., Tomisato, W., Hoshino, T., Ishihara, T., Namba, T., Aburaya, M., Katsu, T., Suzuki, K., Tsutsumi, S., and Mizushima, T. (2005) Involvement of intracellular Ca2+ levels in nonsteroidal anti-inflammatory drug-induced apoptosis. J Biol Chem 280, 31059-31067

 

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