研究業績 - 高知大学農林海洋科学部難波研究室

Yoshioka, T., Igarashi, Y., Namba, T., Ueda, S., Pait, I. G. U., Nihira, T., and Kitani, S. (2021) Lavencidin, a polyene macrolide antibiotic from Streptomyces lavendulae FRI-5. J Antibiot (Tokyo) 74, 359-362
Machihara, K., and Namba, T*. (2020) Kuanoniamine C stimulates bortezomib-induced cell death via suppression of glucose-regulated protein 78 in osteosarcoma. Biochem Biophys Res Commun 527, 289-296
Ueda, S., Ikeda, H., Namba, T., Ikejiri, Y., Nishimoto, Y., Arai, M., Nihira, T., and Kitani, S. (2019) Identification of biosynthetic genes for the beta-carboline alkaloid kitasetaline and production of the fluorinated derivatives by heterologous expression. J Ind Microbiol Biotechnol 46, 739-750
Namba, T*. (2019) BAP31 regulates mitochondrial function via interaction with Tom40 within ER-mitochondria contact sites. Science Advances 5, eaaw1386
Machihara, K., and Namba, T*. (2019) BAP31 Inhibits Cell Adaptation to ER Stress Conditions, Negatively Regulating Autophagy Induction by Interaction with STX17. Cells 8
Ueda, S., Kitani, S., Namba, T., Arai, M., Ikeda, H., and Nihira, T. (2018) Engineered production of kitasetalic acid, a new tetrahydro-beta-carboline with the ability to suppress glucose-regulated protein synthesis. J Antibiot (Tokyo) 71, 854-861
Namba, T*., Kodama, R., Moritomo, S., Hoshino, T., and Mizushima, T. (2015) Zidovudine, an anti-viral drug, resensitizes gemcitabine-resistant pancreatic cancer cells to gemcitabine by inhibition of the Akt-GSK3beta-Snail pathway. Cell Death Dis 6, e1795
Namba, T*., and Kodama, R. (2015) Avarol induces apoptosis in pancreatic ductal adenocarcinoma cells by activating PERK-eIF2alpha-CHOP signaling. Mar Drugs 13, 2376-2389
Namba, T*., Chu, K., Kodama, R., Byun, S., Yoon, K. W., Hiraki, M., Mandinova, A., and Lee, S. W. (2015) Loss of p53 enhances the function of the endoplasmic reticulum through activation of the IRE1alpha/XBP1 pathway. Oncotarget 6, 19990-20001
Namba, T. (2015) Regulation of endoplasmic reticulum functions. Aging (Albany NY) 7, 901-902
Kakigano, A., Tomimatsu, T., Mimura, K., Kanayama, T., Fujita, S., Minato, K., Kumasawa, K., Taniguchi, Y., Kanagawa, T., Endo, M., Ishihara, T., Namba, T., Mizushima, T., and Kimura, T. (2015) Drug Repositioning for Preeclampsia Therapeutics by In Vitro Screening: Phosphodiesterase-5 Inhibitor Vardenafil Restores Endothelial Dysfunction via Induction of Placental Growth Factor. Reprod Sci 22, 1272-1280
Hiraki, M., Hwang, S. Y., Cao, S., Ramadhar, T. R., Byun, S., Yoon, K. W., Lee, J. H., Chu, K., Gurkar, A. U., Kolev, V., Zhang, J., Namba, T., Murphy, M. E., Newman, D. J., Mandinova, A., Clardy, J., and Lee, S. W. (2015) Small-Molecule Reactivation of Mutant p53 to Wild-Type-like p53 through the p53-Hsp40 Regulatory Axis. Chem Biol 22, 1206-1216
Byun, S., Namba, T., and Lee, S. W. (2015) Losing p53 loosens up ER-stress. Aging (Albany NY) 7, 895-896
Namba, T., Tian, F., Chu, K., Hwang, S. Y., Yoon, K. W., Byun, S., Hiraki, M., Mandinova, A., and Lee, S. W. (2013) CDIP1-BAP31 complex transduces apoptotic signals from endoplasmic reticulum to mitochondria under endoplasmic reticulum stress. Cell Rep 5, 331-339
Brown-Endres, L., Schoenfeld, D., Tian, F., Kim, H. G., Namba, T., Munoz-Fontela, C., Mandinova, A., Aaronson, S. A., and Lee, S. W. (2012) Expression of the p53 target CDIP correlates with sensitivity to TNFalpha-induced apoptosis in cancer cells. Cancer Res 72, 2373-2382
Tanaka, K., Tanaka, Y., Miyazaki, Y., Namba, T., Sato, K., Aoshiba, K., Azuma, A., and Mizushima, T. (2011) Therapeutic effect of lecithinized superoxide dismutase on pulmonary emphysema. J Pharmacol Exp Ther 338, 810-818
Takehara, M., Hoshino, T., Namba, T., Yamakawa, N., and Mizushima, T. (2011) Acetaminophen-induced differentiation of human breast cancer stem cells and inhibition of tumor xenograft growth in mice. Biochem Pharmacol 81, 1124-1135
Namba, T., Tanaka, K., Hoshino, T., Azuma, A., and Mizushima, T. (2011) Suppression of expression of heat shock protein 70 by gefitinib and its contribution to pulmonary fibrosis. PLoS One 6, e27296
Hoshino, T., Murao, N., Namba, T., Takehara, M., Adachi, H., Katsuno, M., Sobue, G., Matsushima, T., Suzuki, T., and Mizushima, T. (2011) Suppression of Alzheimer's disease-related phenotypes by expression of heat shock protein 70 in mice. J Neurosci 31, 5225-5234
Tanaka, K., Tanaka, Y., Namba, T., Azuma, A., and Mizushima, T. (2010) Heat shock protein 70 protects against bleomycin-induced pulmonary fibrosis in mice. Biochem Pharmacol 80, 920-931
Tanaka, K., Ishihara, T., Azuma, A., Kudoh, S., Ebina, M., Nukiwa, T., Sugiyama, Y., Tasaka, Y., Namba, T., Ishihara, T., Sato, K., Mizushima, Y., and Mizushima, T. (2010) Therapeutic effect of lecithinized superoxide dismutase on bleomycin-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 298, L348-360
Namba, T., Tanaka, K. I., Ito, Y., Hoshino, T., Matoyama, M., Yamakawa, N., Isohama, Y., Azuma, A., and Mizushima, T. (2010) Induction of EMT-like phenotypes by an active metabolite of leflunomide and its contribution to pulmonary fibrosis. Cell Death Differ 17, 1882-1895
Namba, T., Hoshino, T., Suemasu, S., Takarada-Iemata, M., Hori, O., Nakagata, N., Yanaka, A., and Mizushima, T. (2010) Suppression of expression of endoplasmic reticulum chaperones by Helicobacter pylori and its role in exacerbation of non-steroidal anti-inflammatory drug-induced gastric lesions. J Biol Chem 285, 37302-37313
Suemasu, S., Tanaka, K., Namba, T., Ishihara, T., Katsu, T., Fujimoto, M., Adachi, H., Sobue, G., Takeuchi, K., Nakai, A., and Mizushima, T. (2009) A role for HSP70 in protecting against indomethacin-induced gastric lesions. J Biol Chem 284, 19705-19715
Namba, T., Tanaka, K., Ito, Y., Ishihara, T., Hoshino, T., Gotoh, T., Endo, M., Sato, K., and Mizushima, T. (2009) Positive role of CCAAT/enhancer-binding protein homologous protein, a transcription factor involved in the endoplasmic reticulum stress response in the development of colitis. Am J Pathol 174, 1786-1798
Namba, T., Homan, T., Nishimura, T., Mima, S., Hoshino, T., and Mizushima, T. (2009) Up-regulation of S100P expression by non-steroidal anti-inflammatory drugs and its role in anti-tumorigenic effects. J Biol Chem 284, 4158-4167
Ishihara, T., Tanaka, K., Tasaka, Y., Namba, T., Suzuki, J., Ishihara, T., Okamoto, S., Hibi, T., Takenaga, M., Igarashi, R., Sato, K., Mizushima, Y., and Mizushima, T. (2009) Therapeutic effect of lecithinized superoxide dismutase against colitis. J Pharmacol Exp Ther 328, 152-164
Hoshino, T., Namba, T., Takehara, M., Nakaya, T., Sugimoto, Y., Araki, W., Narumiya, S., Suzuki, T., and Mizushima, T. (2009) Prostaglandin E2 stimulates the production of amyloid-beta peptides through internalization of the EP4 receptor. J Biol Chem 284, 18493-18502
Ushijima, H., Hiasa, M., Namba, T., Hwang, H. J., Hoshino, T., Mima, S., Tsuchiya, T., Moriyama, Y., and Mizushima, T. (2008) Expression and function of TETRAN, a new type of membrane transporter. Biochem Biophys Res Commun 374, 325-330
Tanaka, K., Namba, T., Arai, Y., Fujimoto, M., Adachi, H., Sobue, G., Takeuchi, K., Nakai, A., and Mizushima, T. (2007) Genetic evidence for a protective role for heat shock factor 1 and heat shock protein 70 against colitis. J Biol Chem 282, 23240-23252
Namba, T., Ishihara, T., Tanaka, K., Hoshino, T., and Mizushima, T. (2007) Transcriptional activation of ATF6 by endoplasmic reticulum stressors. Biochem Biophys Res Commun 355, 543-548
Namba, T., Hoshino, T., Tanaka, K., Tsutsumi, S., Ishihara, T., Mima, S., Suzuki, K., Ogawa, S., and Mizushima, T. (2007) Up-regulation of 150-kDa oxygen-regulated protein by celecoxib in human gastric carcinoma cells. Mol Pharmacol 71, 860-870
Ishihara, T., Hoshino, T., Namba, T., Tanaka, K., and Mizushima, T. (2007) Involvement of up-regulation of PUMA in non-steroidal anti-inflammatory drug-induced apoptosis. Biochem Biophys Res Commun 356, 711-717
Tsutsumi, S., Namba, T., Tanaka, K. I., Arai, Y., Ishihara, T., Aburaya, M., Mima, S., Hoshino, T., and Mizushima, T. (2006) Celecoxib upregulates endoplasmic reticulum chaperones that inhibit celecoxib-induced apoptosis in human gastric cells. Oncogene 25, 1018-1029
Tanaka, K., Tomisato, W., Hoshino, T., Ishihara, T., Namba, T., Aburaya, M., Katsu, T., Suzuki, K., Tsutsumi, S., and Mizushima, T. (2005) Involvement of intracellular Ca2+ levels in nonsteroidal anti-inflammatory drug-induced apoptosis. J Biol Chem 280, 31059-31067