{"id":40,"date":"2022-02-04T09:31:39","date_gmt":"2022-02-04T00:31:39","guid":{"rendered":"https:\/\/namba-t-lab.com\/?page_id=40"},"modified":"2022-02-04T11:15:46","modified_gmt":"2022-02-04T02:15:46","slug":"%e7%a0%94%e7%a9%b6%e6%a5%ad%e7%b8%be","status":"publish","type":"page","link":"https:\/\/namba-t-lab.com\/?page_id=40","title":{"rendered":"\u7814\u7a76\u696d\u7e3e"},"content":{"rendered":"<ul>\n<li>Yoshioka, T., Igarashi, Y., <strong>Namba, T<\/strong>., Ueda, S., Pait, I. G. U., Nihira, T., and Kitani, S. (2021) Lavencidin, a polyene macrolide antibiotic from Streptomyces lavendulae FRI-5. <em><strong>J Antibiot (Tokyo)<\/strong><\/em> 74, 359-362<\/li>\n<li>Machihara, K., and <strong>Namba, T*<\/strong>. (2020) Kuanoniamine C stimulates bortezomib-induced cell death via suppression of glucose-regulated protein 78 in osteosarcoma. <em><strong>Biochem Biophys Res Commun<\/strong><\/em> 527, 289-296<\/li>\n<li>Ueda, S., Ikeda, H., <strong>Namba, T<\/strong>., Ikejiri, Y., Nishimoto, Y., Arai, M., Nihira, T., and Kitani, S. (2019) Identification of biosynthetic genes for the beta-carboline alkaloid kitasetaline and production of the fluorinated derivatives by heterologous expression. <em><strong>J Ind Microbiol Biotechnol<\/strong><\/em> 46, 739-750<\/li>\n<li><strong>Namba, T*<\/strong>. (2019) BAP31 regulates mitochondrial function via interaction with Tom40 within ER-mitochondria contact sites. <em><strong>Science Advances<\/strong><\/em> 5, eaaw1386<\/li>\n<li>Machihara, K., and <strong>Namba, T*<\/strong>. (2019) BAP31 Inhibits Cell Adaptation to ER Stress Conditions, Negatively Regulating Autophagy Induction by Interaction with STX17. <em><strong>Cells<\/strong><\/em> 8<\/li>\n<li>Ueda, S., Kitani, S., <strong>Namba, T<\/strong>., Arai, M., Ikeda, H., and Nihira, T. (2018) Engineered production of kitasetalic acid, a new tetrahydro-beta-carboline with the ability to suppress glucose-regulated protein synthesis. <em><strong>J Antibiot (Tokyo)<\/strong><\/em> 71, 854-861<\/li>\n<li><strong>Namba, T*<\/strong>., Kodama, R., Moritomo, S., Hoshino, T., and Mizushima, T. (2015) Zidovudine, an anti-viral drug, resensitizes gemcitabine-resistant pancreatic cancer cells to gemcitabine by inhibition of the Akt-GSK3beta-Snail pathway. <em><strong>Cell Death Dis<\/strong><\/em> 6, e1795<\/li>\n<li><strong>Namba, T*<\/strong>., and Kodama, R. (2015) Avarol induces apoptosis in pancreatic ductal adenocarcinoma cells by activating PERK-eIF2alpha-CHOP signaling. <em><strong>Mar Drugs<\/strong><\/em> 13, 2376-2389<\/li>\n<li><strong>Namba, T*<\/strong>., Chu, K., Kodama, R., Byun, S., Yoon, K. W., Hiraki, M., Mandinova, A., and Lee, S. W. (2015) Loss of p53 enhances the function of the endoplasmic reticulum through activation of the IRE1alpha\/XBP1 pathway. <strong><em>Oncotarget<\/em> <\/strong>6, 19990-20001<\/li>\n<li><strong>Namba, T<\/strong>. (2015) Regulation of endoplasmic reticulum functions. <em><strong>Aging<\/strong> <\/em>(Albany NY) 7, 901-902<\/li>\n<li>Kakigano, A., Tomimatsu, T., Mimura, K., Kanayama, T., Fujita, S., Minato, K., Kumasawa, K., Taniguchi, Y., Kanagawa, T., Endo, M., Ishihara, T., <strong>Namba, T<\/strong>., Mizushima, T., and Kimura, T. (2015) Drug Repositioning for Preeclampsia Therapeutics by In Vitro Screening: Phosphodiesterase-5 Inhibitor Vardenafil Restores Endothelial Dysfunction via Induction of Placental Growth Factor. <em><strong>Reprod Sci<\/strong> <\/em>22, 1272-1280<\/li>\n<li>Hiraki, M., Hwang, S. Y., Cao, S., Ramadhar, T. R., Byun, S., Yoon, K. W., Lee, J. H., Chu, K., Gurkar, A. U., Kolev, V., Zhang, J., <strong>Namba, T<\/strong>., Murphy, M. E., Newman, D. J., Mandinova, A., Clardy, J., and Lee, S. W. (2015) Small-Molecule Reactivation of Mutant p53 to Wild-Type-like p53 through the p53-Hsp40 Regulatory Axis. <em><strong>Chem Biol<\/strong><\/em> 22, 1206-1216<\/li>\n<li>Byun, S., <strong>Namba, T<\/strong>., and Lee, S. W. (2015) Losing p53 loosens up ER-stress. <strong><em>Aging<\/em><\/strong> (Albany NY) 7, 895-896<\/li>\n<li><strong>Namba, T<\/strong>., Tian, F., Chu, K., Hwang, S. Y., Yoon, K. W., Byun, S., Hiraki, M., Mandinova, A., and Lee, S. W. (2013) CDIP1-BAP31 complex transduces apoptotic signals from endoplasmic reticulum to mitochondria under endoplasmic reticulum stress. <em><strong>Cell Rep<\/strong><\/em> 5, 331-339<\/li>\n<li>Brown-Endres, L., Schoenfeld, D., Tian, F., Kim, H. G., <strong>Namba, T.<\/strong>, Munoz-Fontela, C., Mandinova, A., Aaronson, S. A., and Lee, S. W. (2012) Expression of the p53 target CDIP correlates with sensitivity to TNFalpha-induced apoptosis in cancer cells. <em><strong>Cancer Res<\/strong><\/em> 72, 2373-2382<\/li>\n<li>Tanaka, K., Tanaka, Y., Miyazaki, Y., <strong>Namba, T<\/strong>., Sato, K., Aoshiba, K., Azuma, A., and Mizushima, T. (2011) Therapeutic effect of lecithinized superoxide dismutase on pulmonary emphysema. <em><strong>J Pharmacol Exp Ther<\/strong> <\/em>338, 810-818<\/li>\n<li>Takehara, M., Hoshino, T., <strong>Namba, T.<\/strong>, Yamakawa, N., and Mizushima, T. (2011) Acetaminophen-induced differentiation of human breast cancer stem cells and inhibition of tumor xenograft growth in mice. <em><strong>Biochem Pharmacol<\/strong><\/em> 81, 1124-1135<\/li>\n<li><strong>Namba, T<\/strong>., Tanaka, K., Hoshino, T., Azuma, A., and Mizushima, T. (2011) Suppression of expression of heat shock protein 70 by gefitinib and its contribution to pulmonary fibrosis. <em><strong>PLoS One<\/strong><\/em> 6, e27296<\/li>\n<li>Hoshino, T., Murao, N., <strong>Namba, T<\/strong>., Takehara, M., Adachi, H., Katsuno, M., Sobue, G., Matsushima, T., Suzuki, T., and Mizushima, T. (2011) Suppression of Alzheimer&#8217;s disease-related phenotypes by expression of heat shock protein 70 in mice. <em><strong>J Neurosci<\/strong><\/em> 31, 5225-5234<\/li>\n<li>Tanaka, K., Tanaka, Y., <strong>Namba, T<\/strong>., Azuma, A., and Mizushima, T. (2010) Heat shock protein 70 protects against bleomycin-induced pulmonary fibrosis in mice. <em><strong>Biochem Pharmacol<\/strong><\/em> 80, 920-931<\/li>\n<li>Tanaka, K., Ishihara, T., Azuma, A., Kudoh, S., Ebina, M., Nukiwa, T., Sugiyama, Y., Tasaka, Y., <strong>Namba, T<\/strong>., Ishihara, T., Sato, K., Mizushima, Y., and Mizushima, T. (2010) Therapeutic effect of lecithinized superoxide dismutase on bleomycin-induced pulmonary fibrosis. <em><strong>Am J Physiol Lung Cell Mol Physiol<\/strong><\/em> 298, L348-360<\/li>\n<li><strong>Namba, T.<\/strong>, Tanaka, K. I., Ito, Y., Hoshino, T., Matoyama, M., Yamakawa, N., Isohama, Y., Azuma, A., and Mizushima, T. (2010) Induction of EMT-like phenotypes by an active metabolite of leflunomide and its contribution to pulmonary fibrosis. <em><strong>Cell Death Differ<\/strong> <\/em>17, 1882-1895<\/li>\n<li><strong>Namba, T.<\/strong>, Hoshino, T., Suemasu, S., Takarada-Iemata, M., Hori, O., Nakagata, N., Yanaka, A., and Mizushima, T. (2010) Suppression of expression of endoplasmic reticulum chaperones by Helicobacter pylori and its role in exacerbation of non-steroidal anti-inflammatory drug-induced gastric lesions. <em><strong>J Biol Chem<\/strong> <\/em>285, 37302-37313<\/li>\n<li>Suemasu, S., Tanaka, K., <strong>Namba, T<\/strong>., Ishihara, T., Katsu, T., Fujimoto, M., Adachi, H., Sobue, G., Takeuchi, K., Nakai, A., and Mizushima, T. (2009) A role for HSP70 in protecting against indomethacin-induced gastric lesions. <em><strong>J Biol Chem<\/strong><\/em> 284, 19705-19715<\/li>\n<li><strong>Namba, T.<\/strong>, Tanaka, K., Ito, Y., Ishihara, T., Hoshino, T., Gotoh, T., Endo, M., Sato, K., and Mizushima, T. (2009) Positive role of CCAAT\/enhancer-binding protein homologous protein, a transcription factor involved in the endoplasmic reticulum stress response in the development of colitis. <em><strong>Am J Pathol<\/strong><\/em> 174, 1786-1798<\/li>\n<li><strong>Namba, T<\/strong>., Homan, T., Nishimura, T., Mima, S., Hoshino, T., and Mizushima, T. (2009) Up-regulation of S100P expression by non-steroidal anti-inflammatory drugs and its role in anti-tumorigenic effects. <em><strong>J Biol Chem<\/strong><\/em> 284, 4158-4167<\/li>\n<li>Ishihara, T., Tanaka, K., Tasaka, Y., <strong>Namba, T<\/strong>., Suzuki, J., Ishihara, T., Okamoto, S., Hibi, T., Takenaga, M., Igarashi, R., Sato, K., Mizushima, Y., and Mizushima, T. (2009) Therapeutic effect of lecithinized superoxide dismutase against colitis. <em><strong>J Pharmacol Exp Ther<\/strong> <\/em>328, 152-164<\/li>\n<li>Hoshino, T., <strong>Namba, T<\/strong>., Takehara, M., Nakaya, T., Sugimoto, Y., Araki, W., Narumiya, S., Suzuki, T., and Mizushima, T. (2009) Prostaglandin E2 stimulates the production of amyloid-beta peptides through internalization of the EP4 receptor. <em><strong>J Biol Chem<\/strong><\/em> 284, 18493-18502<\/li>\n<li>Ushijima, H., Hiasa, M., <strong>Namba, T<\/strong>., Hwang, H. J., Hoshino, T., Mima, S., Tsuchiya, T., Moriyama, Y., and Mizushima, T. (2008) Expression and function of TETRAN, a new type of membrane transporter. <em><strong>Biochem Biophys Res Commun<\/strong><\/em> 374, 325-330<\/li>\n<li>Tanaka, K., <strong>Namba, T<\/strong>., Arai, Y., Fujimoto, M., Adachi, H., Sobue, G., Takeuchi, K., Nakai, A., and Mizushima, T. (2007) Genetic evidence for a protective role for heat shock factor 1 and heat shock protein 70 against colitis. <strong>J Biol Chem<\/strong> 282, 23240-23252<\/li>\n<li><strong>Namba, T<\/strong>., Ishihara, T., Tanaka, K., Hoshino, T., and Mizushima, T. (2007) Transcriptional activation of ATF6 by endoplasmic reticulum stressors. <em><strong>Biochem Biophys Res Commun<\/strong><\/em> 355, 543-548<\/li>\n<li><strong>Namba, T<\/strong>., Hoshino, T., Tanaka, K., Tsutsumi, S., Ishihara, T., Mima, S., Suzuki, K., Ogawa, S., and Mizushima, T. (2007) Up-regulation of 150-kDa oxygen-regulated protein by celecoxib in human gastric carcinoma cells. <em><strong>Mol Pharmacol<\/strong><\/em> 71, 860-870<\/li>\n<li>Ishihara, T., Hoshino, T., <strong>Namba, T<\/strong>., Tanaka, K., and Mizushima, T. (2007) Involvement of up-regulation of PUMA in non-steroidal anti-inflammatory drug-induced apoptosis. <em><strong>Biochem Biophys Res Commun<\/strong><\/em> 356, 711-717<\/li>\n<li>Tsutsumi, S., <strong>Namba, T.<\/strong>, Tanaka, K. I., Arai, Y., Ishihara, T., Aburaya, M., Mima, S., Hoshino, T., and Mizushima, T. (2006) Celecoxib upregulates endoplasmic reticulum chaperones that inhibit celecoxib-induced apoptosis in human gastric cells. <em><strong>Oncogene<\/strong><\/em> 25, 1018-1029<\/li>\n<li>Tanaka, K., Tomisato, W., Hoshino, T., Ishihara, T., <strong>Namba, T<\/strong>., Aburaya, M., Katsu, T., Suzuki, K., Tsutsumi, S., and Mizushima, T. (2005) Involvement of intracellular Ca2+ levels in nonsteroidal anti-inflammatory drug-induced apoptosis. <em><strong>J Biol Chem<\/strong><\/em> 280, 31059-31067<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Yoshioka, T., Igarashi, Y., Namba, T., Ueda, S., Pait, I. G. U., Nihira, T., and Kitani, S. (2021) L &#8230; <\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/namba-t-lab.com\/index.php?rest_route=\/wp\/v2\/pages\/40"}],"collection":[{"href":"https:\/\/namba-t-lab.com\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/namba-t-lab.com\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/namba-t-lab.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/namba-t-lab.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=40"}],"version-history":[{"count":4,"href":"https:\/\/namba-t-lab.com\/index.php?rest_route=\/wp\/v2\/pages\/40\/revisions"}],"predecessor-version":[{"id":81,"href":"https:\/\/namba-t-lab.com\/index.php?rest_route=\/wp\/v2\/pages\/40\/revisions\/81"}],"wp:attachment":[{"href":"https:\/\/namba-t-lab.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=40"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}